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Foundations of Amyloidosis

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crk.cro
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August 14, 2026

Foundations of Amyloidosis

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Foundations of Amyloidosis, Free courses, Short Courses

Foundations of Amyloidosis

What Will I Learn?

  • Explain the normal structure and function of proteins and how amyloid fibrils form.
  • Describe the pathophysiology of systemic amyloidosis and its effects on different organs, particularly the heart.
  • Differentiate the major amyloidosis subtypes, including AL, ATTR, and AA amyloidosis.
  • Distinguish hereditary transthyretin amyloidosis (hATTR) from wild-type transthyretin amyloidosis (wtATTR).
  • Understand the genetic basis, inheritance patterns, and geographic distribution of hATTR, with emphasis on African populations.
  • Recognize why cardiac amyloidosis is frequently underdiagnosed and often mistaken for more common cardiovascular diseases.
  • Identify the major barriers to timely diagnosis, treatment access, and specialist care in low- and middle-income countries.
  • Appreciate the impact of healthcare systems, policy, and socioeconomic factors on patient outcomes.
  • Explore emerging advances in diagnostics, therapies, digital health, and international collaborations that aim to improve equity in amyloidosis care.
  • Build a strong scientific foundation for the subsequent modules on clinical presentation, diagnosis, imaging, and treatment.

Course Content

Module 1: Foundations of Transthyretin Amyloidosis
Understanding Amyloidosis: Biology, Hereditary Risk, and Global Barriers to Care: This module lays the foundation for understanding amyloidosis, with a focus on its cardiac manifestations and global disparities in diagnosis and care. Learners are introduced to the pathophysiology of systemic amyloidosis, the classification of major subtypes (including AL, ATTR, and AA), and the critical distinction between hereditary and wild-type transthyretin amyloidosis (hATTR and wtATTR). Special emphasis is placed on the genetic diversity and underdiagnosis of hATTR in African-descended populations. The module concludes with a discussion of structural, economic, and policy barriers to early detection and treatment, especially in low-resource settings such as Kenya, while highlighting future innovations that can support more equitable care delivery.

  • Pre-test: Foundations of Transthyretin Amyloidosis
  • Introduction
  • Lesson 1: Introduction to Amyloidosis
    13:11
  • Lesson 2: Hereditary ATTR Amyloidosis
    00:00
  • Lesson 3: Barriers and Future Directions in ATTR-CM Care
  • Assessment test: Foundations of Transthyretin Amyloidosis

About the instructor

C

crk.cro

CRK is Kenyan’s largest and most comprehensive provider of post-graduate training courses in clinical research, public health, pharmaceutical sciences, and various other domains. At CRK-CRO, we believe a properly trained and competent health workforce is essential to any successful healthcare system.

 4.76 (255 ratings)

5 Courses

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Free
Free access this course
  • Certificate of completion
Durations:
Lectures: 4
Students: Max 0
Level: Beginner
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