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August 14, 2026

ATTR Cardiac Amyloidosis Subtyping

ATTR Cardiac Amyloidosis Subtyping

What Will I Learn?

  • Describe the pathophysiology, subtypes, and burden of TTR amyloidosis.
  • Identify clinical, ECG, and imaging red flags suggestive of ATTR-CM.
  • Apply diagnostic algorithms using monoclonal protein screening, bone scintigraphy, biopsy, and genetic testing.
  • Interpret cardiac MRI and echocardiographic findings relevant to amyloidosis.
  • Choose evidence-based therapies and manage mutation carriers.
  • Analyze clinical cases to avoid misdiagnosis and diagnostic delays.

Course Content

ATTR-CM Comprehensive Knowledge Assessment

  • ATTR-CM Comprehensive Knowledge Assessment (Note: This quiz is for knowledge assessment only; no points will be awarded)

Module 4: Subtype Classification in Cardiac Amyloidosis: Tissue Biopsy, Genetic Testing, and Cardiac MRI (Steps 3 and 4)
After red flag identification and nuclear imaging, precise classification of amyloid subtype becomes critical to guide treatment. This module covers Steps 3 and 4 of the ATTR-CM diagnostic algorithm, focusing on diagnostic stratification through tissue biopsy, genetic sequencing, and multiparametric CMR imaging. Learners will master the decision-making process when imaging and lab findings are discordant, distinguish hereditary from wild-type ATTR, and interpret imaging biomarkers for disease burden and prognosis. The module aligns with international consensus guidelines (ESC, AHA, ACC) and prioritizes applicability in African settings, where hereditary forms may be under-recognized and misclassified.

ATTR-CM Comprehensive Knowledge Assessment Quiz

About the instructors

John Heshmat is a pharmacist and public health professional with over a decade of diverse experience in clinical research, health education, and humanitarian service across Africa. He holds a Master’s in International Public Health from Liverpool John Moores University and a Bachelor of Pharmacy from October 6 University.

As the Clinical Operations Manager at CRK Clinical Research Key (CRO), John leads high-impact clinical research and capacity-building programs targeting underserved populations in Kenya. He also serves as the Country Coordinator for Mécénat Chirurgie Cardiaque, a global organization that sponsors life-saving heart surgeries for children with congenital heart defects.

At CRKCourses.com, John combines scientific rigor with practical field insight to deliver CME/CPD-accredited e-learning programs for healthcare professionals. His teaching emphasizes evidence-based practice, health equity, and the real-world application of research in resource-limited settings.

With a passion for public service and training the next generation of African health leaders, John is committed to improving patient outcomes through education, innovation, and collaborative learning.

4.81 (242 ratings)

3 Courses

3900 students

CRK is Kenyan’s largest and most comprehensive provider of post-graduate training courses in clinical research, public health, pharmaceutical sciences, and various other domains. At CRK-CRO, we believe a properly trained and competent health workforce is essential to any successful healthcare system.

4.76 (255 ratings)

5 Courses

0 students

Free
Free access this course
Durations:
Lectures: 7
Students: Max 0
Level: Beginner
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